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A third study found that high fructose levels reversed leptin resistance in rats given a high fat diet. Views Read Edit View history. However, today we recognise that there is also a metabolic component which explains why obesity is a risk factor for osteoarthritis, not only for weight-bearing joints for example, the knees , but also for joints that do not bear weight for example, the hands. In other projects Wikimedia Commons. Available structures PDB Ortholog search:


There are no serious side effects, only some reports of mild digestive issues (14). It is best to get a brand with at least 50 Hydroxycitric acid. The most common dosage is 500 mg, 3 times per day, half an hour before meals.